Development and validation of new analytical method for the estimation of fluoxetine in bulk and dosage form by UV spectrophotometry

  • K. Uday sankar raju Department of Pharmaceutical Analysis, P. Rami Reddy Memorial college of pharmacy, Kadapa, India.
  • T. Vimalakkannan Department of Pharmaceutical Analysis, P. Rami Reddy Memorial college of pharmacy, Kadapa, India.
  • K. Ravindra Reddy Department of Pharmaceutics, P. Rami Reddy Memorial college of pharmacy, Kadapa, India.
  • P. Naveena Department of Pharmaceutical Analysis, P. Rami Reddy Memorial college of pharmacy, Kadapa, India.
  • R. Riharika raj Department of Pharmaceutical Analysis, P. Rami Reddy Memorial college of pharmacy, Kadapa, India.
  • S. Chinna subbarayudu Department of Pharmaceutical Analysis, P. Rami Reddy Memorial college of pharmacy, Kadapa, India.
  • T. Hima bindu Department of Pharmaceutical Analysis, P. Rami Reddy Memorial college of pharmacy, Kadapa, India.
DOI: https://doi.org/10.33974/ijrpca.v1i2.54
Keywords: Fluoxetine, UV Spectrophotometry

Abstract

A simple, rapid and precise method is developed for the quantitative determination of Fluoxetine in combined pharmaceutical-dosage forms. The method was based on UV Spectrophotometric determination of Fluoxetine drug using Beer-Lamberts Law. It involves absorbance measurement at 224 nm (λmax of Fluoxetine) in water. For UV Spectrophotometric method, linearity was obtained in concentration range of 5-30 mcg/ml with regression 0.999 for Fluoxetine respectively. Recovery was in the range of 98 -102%; the value of standard deviation and %R.S.D was found to be < 2 shows high precision of the method..

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Published
27-03-2019
How to Cite
K, U. sankar raju, T, V., K. Ravindra Reddy, P. Naveena, R. Riharika raj, S. Chinna subbarayudu, & T. Hima bindu. (2019). Development and validation of new analytical method for the estimation of fluoxetine in bulk and dosage form by UV spectrophotometry. International Journal of Research In Pharmaceutical Chemistry and Analysis, 1(2), 36-39. https://doi.org/10.33974/ijrpca.v1i2.54
Issue
Vol 1 No 2 (2019): Volume 1 Issue 2
Section
Research Article

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