Spectrophotometric determination and estimation of minoxidil in tablet dosage form by UV

  • S. Khadeerunnisa Department of Pharmaceutical Analysis, P. Rami Reddy Memorial College of Pharmacy, Andhra Pradesh, India.
  • T. VimalakKannan Department of Pharmaceutical Analysis, P. Rami Reddy Memorial College of Pharmacy, Andhra Pradesh, India.
  • T. Vijaya Lakshmi Department of Pharmaceutical Analysis, P. Rami Reddy Memorial College of Pharmacy, Andhra Pradesh, India.
Keywords: Minoxidil, 0.1N HCl, UV- spectroscopy, Validation

Abstract

A simple, precise, accurate and economical UV spectrophotometric method has been developed and validated for the estimation of Minoxidil in the tablet dosage form. Minoxidil shows maximum absorbance at 279.4nm. The method was carried out by using 0.1N HCl as a solvent. The drug shows linearity from the concentration range of 1-6µg/ml and correlation coefficient was found to be 0.9992. The proposed method was statistically validated for precision, accuracy, ruggedness, robustness, the limit of detection, quantitation as per the ICH guidelines. Hence this method can be successfully applied for routine analysis of Minoxidil in bulk and tablet dosage form.

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Published
06-05-2019
How to Cite
S. Khadeerunnisa, T. VimalakKannan, & T. Vijaya Lakshmi. (2019). Spectrophotometric determination and estimation of minoxidil in tablet dosage form by UV. International Journal of Research In Pharmaceutical Chemistry and Analysis, 1(2), 47-51. Retrieved from https://journals.krishviphysiocare.in/index.php/ijrpca/article/view/73
Issue
Vol 1 No 2 (2019): Volume 1 Issue 2
Section
Research Article